(French New DC) scientists at the University of Minnesota announced on Wednesday that the effectiveness of the men's oral contraceptives in animal tests is as high as 99 % and there are no obvious side effects.Researchers are expected to start human tests by the end of this year. If everything goes well, this drug is expected to be listed within five years.
The test results show that the number of sperm has decreased significantly after taking this new drug YCT529 four weeks after taking this new drug, and the contraceptive rate during mating with female reaches 99 %.
After four to six weeks, their fertility ability is recovered.Researchers also observed the weight, food and activity of mice, and did not find obvious side effects.
Since the birth of women's contraceptives in the 1960s, scientists have begun to develop male contraceptives.
A number of surveys show that many men are also willing to bear the responsibility of birth.However, there are only two valid options for men. Even if it is condom or performed vascular resection, the latter costs expensive and may not be successful.
Women's oral contraceptives use hormones to disturb the menstrual cycle. Male contraceptives developed in the past also aimed at male hormone testosterone. However, such drugs often have side effects, including may cause weight gain, depression, increase the heartDisease risk, etc.
The team of the University of Minnesota focuses on a protein called Rar-α (RAR-α), called RetinoicAcidReceptivePTORALPHA (RAR-α), a compound called a compound that can block RAR-α.
It is important to treat cottonic acid for cell growth, sperm formation and embryo development, but it must interact with RAR-α to achieve effect.Past studies have shown that the lack of this gene will cause mice to be infertile.
