Significant toxicity reduces the trend, but there is still aggressiveness for fragile people, especially for people over 80 years old, as well as patients with chronic kidney disease, hypertension, and some nervous system diseases.Not Zhang Wenhong reiterated that because most of the deaths or severe cases occur in people who have no vaccine, vaccination is very critical to protect the fragile people.He made three suggestions. First, once infection, if there are symptoms, sufficient drug treatment is required; second, the vaccine is fully vaccinated; third, a reverse protection during the period of great popularity to avoid viruses from entering the life of fragile crowds.space.