The remarks have thrown doubt over the U.S. commitment to defend Taiwan if Trump becomes president and in the event of an attack by China, which sees the democratically governed island as part of its territory.
The Taiwan-listed shares of Taiwan Semiconductor Manufacturing Co. closed down 2.4% on Wednesday.
The geopolitical tensions also weighed on chip stocks in the U.S. The closed down over 7%. and were among the other U.S.-listed laggards in trading.