On October 15, 2018, Harbin Medical University held a school-wide cadre meeting, announcing that Zhang Xue was the president of Harbin Medical University, deputy secretary of the party committee, and president of the Heilongjiang Academy of Medical Sciences.

Zhang Xue (data map)

Half a month ago, the Organization Department of the Heilongjiang Provincial Party Committee issued a pre-appointment announcement, notifying Zhang Xue, the vice president of the Chinese Academy of Medical Sciences and Peking Union Medical College, to be the deputy secretary of the Party Committee of Harbin Medical University, and nominated as the president of Harbin Medical University and Heilongjiang Academy of Medical Sciences.long.

In the pre-appointment announcement, the Organization Department of the Heilongjiang Provincial Party Committee also specifically pointed out: Zhang Xue is a Changjiang Scholars Distinguished Professor and a leading talent in the National High-Level Talents Special Support Plan for the Ten Million Project.

This time Zhang Xue served as the president of Harbin Medical University, deputy secretary of the party committee, and president of the Heilongjiang Academy of Medical Sciences, which means that he has passed the publicity assessment of the term of office for exceptional promotion.

According to Heilongjiang Daily, Zhang Qingwei, Secretary of the Heilongjiang Provincial Party Committee, had a talk with Zhang Xue before he formally took office.Zhang Qingwei pointed out that the Heilongjiang Provincial Party Committee attaches great importance to the province's higher education and talent work, and Zhang Xue's appointment as the president of Harbin Medical University fully reflects the provincial Party Committee's high attention to talent introduction and its deep concern for the leadership of provincial universities.

The Heilongjiang Provincial Party Committee welcomed Zhang to work in Heilongjiang.So how good is Zhang Xue, the exceptionally promoted cadre Zhang Xue who was appointed as the secretary of the provincial party committee?

According to the public resume, Zhang Xue was born in July 1964, from Zhaozhou County, Heilongjiang Province, with a postgraduate degree and a professor of medical genetics.

During the eight years from 1986 to 1994, Zhang Xue studied at China Medical University for undergraduate, master, and doctor degrees.

After graduating in 1994, Zhang Xue stayed at the school to teach for 7 years, and successively served as a teaching assistant, lecturer, professor and director of the Cell Biology Teaching and Research Section of the School of Basic Medical Sciences, China Medical University.

During this period, Zhang Xue was awarded the National Science Fund for Distinguished Young Scholars.He has studied and worked in the National Cancer Center of Japan, the University of Pennsylvania, Harvard Medical School/Massachusetts General Hospital Cancer Center, and Harvard School of Dental Medicine.

In 2001, Zhang Xue was transferred to the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences - Director of the Department of Medical Genetics, School of Basic Medicine, Peking Union Medical College.

The Chinese Academy of Medical Sciences is the only national medical science academic center and comprehensive medical science research institution in my country, and Peking Union Medical College is the earliest key medical school in my country.The two implement the management system of the integration of colleges and universities. The Academy of Medical Sciences provides teachers and technical strength for the Union Medical College, and the Union Medical College trains high-level talents for the Medical Academy.

In Peking Union Medical College, Chinese Academy of Medical Sciences, Zhang Xue has worked for 17 years, successively served as assistant to the president of Chinese Academy of Medical Sciences - Assistant to the president of Peking Union Medical College, vice president of Graduate School of Chinese Academy of Medical Sciences - Peking Union Medical College, ChinaDirector of Science and Technology Management Office of Peking Union Medical College, Academy of Medical Sciences, Secretary of the Party Committee of Institute of Basic Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, etc.

Last year, Zhang Xuesheng served as the vice president of the Chinese Academy of Medical Sciences, the vice president of Peking Union Medical College, and became a deputy department-level cadre.Director of the Hospital's Clinical Genetics Laboratory.

After serving as a deputy department-level cadre for more than a year, Zhang Xue returned to his hometown of Heilongjiang to work this time. He served as the president of Harbin Medical University, deputy secretary of the party committee, dean of the Heilongjiang Academy of Medical Sciences, and was promoted to a department-level cadre.

According to the official website of the Chinese Academy of Medical Sciences-Peking Union Medical College: Zhang Xue is mainly engaged in the molecular genetics research of single-gene diseases and genomic diseases, and has discovered the causative genes of various single-gene diseases and the pathogenic DNA rearrangement of genomic diseases.Published many papers in journals such as Nature Genetics.In 2001, he was awarded the National Science Fund for Distinguished Young Scholars. In 2007, he was selected as a Distinguished Professor of the Changjiang Scholars of the Ministry of Education. In 2014, he won the second prize of the National Natural Science Award as the first author. In 2017, he won the National Innovation Award.

The 2010 annual report of the National Natural Science Foundation of China introduced the academic leaders of the National Science Fund for Distinguished Young Scholars and innovative research groups, introducing Zhang Xue's academic achievements at that time.

According to the report, Zhang Xue's main research direction is the identification of single-gene genetic disease-causing genes and genomic disease-causing copy number variations. Representative achievements mainly include the following three.

(1) Identification of pathogenic genes of familial acne inversa.Acne inverso, also known as the follicular atresia triad, is a chronic, recurrent inflammatory skin disease.Loss-of-function mutations in the gamma;-secretase complex catalytic subunit presenilin 1 coding gene PSEN1 or PEN2 subunit coding gene PSENEN or nicastrin subunit coding gene NCSTN were found in all six acne inversa families studied,Revealed that the molecular pathogenesis of acne inversion is a defect in the gamma;-secretase-Notch pathway, suggesting that early-onset familial Alzheimer's disease and familial acne inversion can be the result of different types of mutations in the PSEN1 gene.It provides a theoretical basis for the selection of different drug targets for the treatment of different diseases.

(2) Discovery of new pathogenic mutation mechanism of Marie Unna hereditary hypotrichosis.In 19 families from ten countries, different types of point mutations in the open reading frame U2HR upstream of the hairless gene HR were found, which proved that the U2HR mutation can lead to an increase in the translation level of the HR gene, indicating that the precise regulation of the translation level of the HR gene is in the hairPlays an important role in normal circulation and growth processes.

(3) Identification of pathogenic copy number variations in congenital generalized hypertrichosis.Microdeletions in the chromosome 17q24 region were found in three Chinese families, and microduplications in the chromosome 17q24 region were found in a sporadic individual with severe generalized hirsutism and gingival hyperplasia, indicating a hairy pattern that has long been considered an atavistic phenomenon.Man or Werewolf Syndrome is actually a genetic disease.

In 2016, on the occasion of the 60th anniversary of the establishment of the Chinese Academy of Medical Sciences, the top ten scientific and technological achievements in the 60 years since the establishment of the Academy were selected.Among them, the ninth item of cytogenetics creation and gene research on genetic diseases and complex trait diseases mentioned that two research groups, Shen Yan and Zhang Xue, have successively discovered genetic opalescent dentin, familial abnormal acne, and MarieUnna type inheritanceThe causative genes of monogenic diseases such as hypotrichosis and erythromelalgia, identified the DNA rearrangement of genomic diseases such as congenital generalized hirsutism, and published a series of papers in journals such as Science and Nature Genetics, resulting in major internationalAcademic impact, related achievements won two second prizes of the National Natural Science Awards.

Heilongjiang Daily reported that Zhang Xuehuo's extraordinary promotion to work in Heilongjiang is an active attempt and an important breakthrough in the province's talent introduction strategy.

Not long ago, Shanxi also introduced a Changjiang scholar, Huang Guitian, who was promoted from the director level to the department level cadre.

On September 30, Huang Guitian officially became the deputy secretary of the party committee and president of Shanxi University. Before that, he was the director of the Office of the Industrial Management Committee of Peking University (director level).