According to the news on June 24, the public account of the China Military Network, Chinese scientists have made major breakthroughs in the research of new coronary virus antibodies. The team led by Chen Wei, a member of the Chinese Academy of Engineering and a researcher at the Military Medical Research Institute of Military Sciences, discovered the first targeted thornsHigh -efficiency neutralized and monoclonal antibodies in the N -terminal domain.
Chen Weitu 丨 China Military Network
At 22:00 on June 22, Beijing time, the top international academic journal science published the results of the research online.This is also another world -class scientific research result that the new crown vaccine developed by Chen Wei's team developed by the adenovirus carrier in the phase II.The first author of the paper is Chi Xiangyang, Xun Renhong, and Zhang Jun; the author of the communications is Chen Wei, Zhou Qiang, and Li Jianmin.
Online screenshot of the article.Provided by the Military Medical Research Institute
At present, the new coronary pneumonia epidemic is raging all over the world. The development of safe and effective vaccines and antibodies is a major challenge facing scientists in various countries. The vaccine is used for the prevention of healthy people.EssenceSince the outbreak of the new coronary pneumonia, Academician Chen Wei went to Wuhan for the first time, leading the team to carry out emergency scientific research on emergency scientific research on the original spread of diseases, rapid detection technology, and vaccine antibody development, and achieved a series of important scientific research results.
The structural diagram of S protein and 4A8 antibodies.Provided by the Military Medical Research Institute
Neutral antibodies are a type of antibody that produces a protective effect produced by the body's response to the original stimulus.At present, the research and mechanism research of various scientific research teams around the world focuses on the receptor -binding domain of the new coronary virus spiny protein, while the Chen Wei team recognizes the efficient neutralization of the N -end domain of the spy protein N -end domain.The cloning antibody found that the N -terminal domain is a new vulnerable surface of the new coronary virus spiny protein, which provides new effective targets for therapeutic antibodies and other drug design.
Chen Wei team cooperated with the Zhou Qiang team of Xihu University to analyze the interaction interface of antibodies and spiny protein with high precision technology, providing key information for clarifying its antiviral mechanism.The antibody can play a high -level virus neutral when used alone, and can also be used as an efficient cocktail therapy with antibodies against receptor -binding domains.This provides strong candidate drugs for the treatment of new crown pneumonia, and also provides new ideas for the research of drugs and surface vaccine design and new coronal virus in targeted spiny protein N -terminal domain, which provides new ideas.
